My second TechEd talk was about managing the registry with Windows PowerShell. If you were in the session you know that I stressed heavily using the PowerShell provider and cmdlets. For remote computers, leverage PowerShell's remoting infrastructure. But I also discussed using the "raw" .NET classes as well as WMI (if you are really desperate and like a challenge).
The session video can be found on the TechEd North America site here. A zip file with the demos, a transcript and PDF of the slide deck can be downloaded here.